Endocrine Abstracts

Introduction: Adrenal insufficiency (AI) requires lifelong steroid replacement therapy, traditionally with hydrocortisone (HC), which, taken in divided doses, mimics the normal daytime cortisol profile. Prednisolone, with its longer duration of action, presents a cost-effective, once-daily alternative, yet its comparative efficacy and safety profile in AI management still need to be explored. Therefore, the current study aims to assess the metabolic and cardiovascular outcomes...

Introduction: Typically, patients with a microprolactinoma will have serum prolactin level between 2,000-4,000mIU/l. The primary goal of treatment is to normalise prolactin level and thereby improve symptoms associated with a raised prolactin. Dopamine (D2) agonists are the main stay of treatment with some patients unable to tolerate dopamine agonists rather than being resistant to the medication.Case report: A 26-year-old lady with a history of anxiety ...

Introduction: Pituitary apoplexy is an endocrinological emergency that can be life-threatening if treatment is delayed. Apoplexy occurs either due to haemorrhage or infarction of a pituitary tumour.Case History: A 19-year-old male, presented with a sudden severe headache and visual disturbances. The examination was normal with stable haemodynamic parameters and tanner staging 5. An urgent MRI pituitary revealed a haemorrhagic pituitary macroadenoma compr...

Introduction: Graves thyrotoxicosis can be life-threatening if uncontrolled. Resistant thyrotoxicosis is not uncommon and may require urgent intervention. We present a case with severe refractory thyrotoxicosis which required urgent total thyroidectomy following bridging plasma exchange.Case History: A 35-year-old male with Grave’s disease presented with persistent thyrotoxic symptoms despite medical management for 10 months. Clinically he was hyper...

Diagnosis of Cushing’s syndrome is challenging in the absence of cardinal features. But still, they have the same metabolic risk due to the presence of biochemical hypercortisolism. A 35-year lady was referred to the tertiary care endocrine unit following an incidental finding of high cortisol levels while on treatment for covid in 2021. She also had some weight gain, slow healing of wounds, and easy bruising. She did not have any features of hyperandrogenism and hyperten...